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Other Names for Noopept

GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester, Ноопепт, (CAS Number) 157115-85-0, (PubChem) CID 180496, C17H22N2O4

Important Information

Dosing Noopept

Among the studies cited, the effective doses ranged from .01mg/kg to 10 mg/kg (in rats and mice); when subjected to allometric scaling, this range would be equivalent to .002mg/kg to 2.445 mg/kg in humans [7,10,13].  In a 70kg (154lbs) adult human, the dosing range would be 171mcg to 171mg.

Typically, the most cited dosing range (anecdotally) is 10-30mg, up to 3 times per day, usually dosed sublingually or orally.

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Noopept Background

Patented in 1995, Noopept is a Nootropic substance that is a dipeptide similar in effect to Piracetam [3]; it is often cited as being 1000 times more potent (by weight) than Piracetam.  Noopept has high oral bioavailability, and appears to potentiate its own effects with chronic administration.  Noopept has shown promise in treating many different aspects of cognitive decline that warrants more research, especially in human models.

Noopept’s Mechanism of Action

Noopept has been noted to have four main mechanisms of action; the first noted mechanism of action is antioxidation: in vitro studies of Noopept have shown signs that it operates on an antioxidative mechanism of action which protects neurons from apoptosis [4].  The second noted mechanism of action of Noopept is inhibition of glutamate neurotoxicity [1]; glutamate neurotoxicity leads to quick cell death, and is linked to a variety of neurological disorders such as autism and Alzheimer’s disease.  The third mechanism of action of Noopept is increased neuronal plasticity [7], which can lead to greater adaptability in learning and memory.  The fourth mechanism of action that has been noted in Noopept is increases expression of phenylacetic acid, prolyglycine, and cyclo-prolyglycine in the brain [12], which are endogenous Nootropics. To get more information visit #noopept.